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Regularly alluded to as anabolic steroids, these enhancements and infusions are introduced in both common and manufactured structures. Anabolic androgenization and hyperandrogenization are, therefore, considered to take place in the liver but not in the kidneys as some researchers believe.[11,20] Anabolic steroids also affect other systems, notably the central nervous system. However, this is not well studied. Most of this research has come from animals. Efficacy research has established that these performance enhancing androgenic agents can produce significant improvements in athletic performance, as well as the development of lean body mass. They have also been shown to suppress muscle shrinkage, fat loss, and improve endurance in humans. There has also been an increase in the strength, power, and stamina level at anabolic steroid dosages. Anabolic steroid use during pregnancy has been associated with increased risk of low birth weight, preterm labor, low birth weight, and fetal alcohol spectrum disorders. Anabolic steroids should be avoided during pregnancy, as the potential risk for a potential adverse effects of this substance exceeds the risks of nonsteroidal anti-inflammatory drugs (NSAIDs), and even aspirin. Anabolic Steroid Dependence An adverse effect of one form of anabolic steroids may not require the elimination of all the other forms, as long as the two are avoided under all circumstances. There has been some controversy as to whether the more common form of anabolic steroid, LHRH, should be used in combination with an LHRH receptor agonist to prevent LHRH-induced breast cancer. The risk for breast cancer when the two are used together is greater than that when the two are separately; however, this is not well researched. The effects of all these chemicals do not come without their risk. One study showed that pregnant women taking anabolic steroids over an extended period of time also had increased risk of early death after taking breast cancer chemotherapy. Other adverse effects have come to light in the same type of studies; for example, the increased risk of hypertension, stroke, and type 2 diabetes appears to be linked only to an LHRH-induced increase in serum creatinine. Allergies Lethal Anaphylactic Reaction A number of drugs are known to cause a type of "lethal or self-analysing anaphylactic reaction involving allergic reactions in humans" in which the immediate respiratory tract is reactivated with anaphylaxis (an Related Article: